Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider (Latrodectus tredecimguttatus)

Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider (Latrodectus tredecimguttatus)

Widow spiders are among the few spider species worldwide that can cause serious envenoming in humans. The clinical syndrome resulting from Latrodectus spp. envenoming is called latrodectism and characterized by pain (local or regional) associated with diaphoresis and nonspecific systemic effects. Th...

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Bibliographic Details
Main Authors: Sofie Føns, Line Ledsgaard, Maxim V. Nikolaev, Alexander A. Vassilevski, Christoffer V. Sørensen, Manon K. Chevalier, Michael Fiebig, Andreas H. Laustsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
envenoming
spider toxins
latrotoxin
monoclonal antibodies
phage display
widow spiders
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.587825/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.587825/full

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