Exploring the role of fatigue-related metabolite activity during high-intensity exercise using a simplified whole-body mathematical model

Intense exercise leads to muscle fatigue, a contractile and metabolic failure of contracting muscle to sustain desired work. It is widely accepted that the close relationship between intense exercise and the accumulation of metabolic by-products is the major cause of skeletal muscle fatigue. High-in...

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Bibliographic Details
Main Authors: Yuttamol Muangkram, Megumi Honda, Akira Amano, Yukiko Himeno, Akinori Noma
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914820301702