PD-1-Targeted Discovery of Peptide Inhibitors by Virtual Screening, Molecular Dynamics Simulation, and Surface Plasmon Resonance

PD-1-Targeted Discovery of Peptide Inhibitors by Virtual Screening, Molecular Dynamics Simulation, and Surface Plasmon Resonance

The blockade of the programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) pathway plays a critical role in cancer immunotherapy by reducing the immune escape. Five monoclonal antibodies that antagonized PD-1/PD-L1 interaction have been approved by the Food and Drug Administrati...

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Bibliographic Details
Main Authors: Yuanqiang Wang, Haiqiong Guo, Zhiwei Feng, Siyi Wang, Yuxuan Wang, Qingxiu He, Guangping Li, Weiwei Lin, Xiang-Qun Xie, Zhihua Lin
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
pd-1
peptides
molecular docking
molecular dynamics (md) simulation
surface plasmon resonance (spr)
Online Access:https://www.mdpi.com/1420-3049/24/20/3784

Internet

https://www.mdpi.com/1420-3049/24/20/3784

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