Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus

Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus

It is challenging to characterize diverse transcript isoforms by short-read sequencing. Here the authors report full-length transcriptomes in rat hippocampus by hybrid-sequencing, predict isoform-specific translational status, and reconstruct open reading frames validated by mass spectrometry.

Bibliographic Details
Main Authors: Xi Wang, Xintian You, Julian D. Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin M. Schuman, Wei Chen
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13037-0

Internet

https://doi.org/10.1038/s41467-019-13037-0

Similar Items