Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus
It is challenging to characterize diverse transcript isoforms by short-read sequencing. Here the authors report full-length transcriptomes in rat hippocampus by hybrid-sequencing, predict isoform-specific translational status, and reconstruct open reading frames validated by mass spectrometry.
Bibliographic Details
| Main Authors: |
Xi Wang,
Xintian You,
Julian D. Langer,
Jingyi Hou,
Fiona Rupprecht,
Irena Vlatkovic,
Claudia Quedenau,
Georgi Tushev,
Irina Epstein,
Bernhard Schaefke,
Wei Sun,
Liang Fang,
Guipeng Li,
Yuhui Hu,
Erin M. Schuman,
Wei Chen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-13037-0
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