A novel PGAM5 inhibitor LFHP-1c protects blood–brain barrier integrity in ischemic stroke

A novel PGAM5 inhibitor LFHP-1c protects blood–brain barrier integrity in ischemic stroke

Blood–brain barrier (BBB) damage after ischemia significantly influences stroke outcome. Compound LFHP-1c was previously discovered with neuroprotective role in stroke model, but its mechanism of action on protection of BBB disruption after stroke remains unknown. Here, we show that LFHP-1c, as a di...

Full description

Bibliographic Details
Main Authors: Chenglong Gao, Yazhou Xu, Zhuangzhuang Liang, Yunjie Wang, Qinghong Shang, Shengbin Zhang, Cunfang Wang, Mingmin Ni, Dalei Wu, Zhangjian Huang, Tao Pang
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ischemic stroke
Blood–brain barrier
Brain microvascular endothelial cells
Target identification
Surface plasmon resonance
PGAM5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000101

Internet

http://www.sciencedirect.com/science/article/pii/S2211383521000101

Similar Items