Slow viral propagation during initial phase of infection leads to viral persistence in mice

Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as a mechanism for immune evasion and viral persiste...

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Main Authors:	Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02028-x

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spelling	doaj-e64f13b539b04accba130bd3d10b58442021-05-02T11:28:54ZengNature Publishing GroupCommunications Biology2399-36422021-04-014111210.1038/s42003-021-02028-xSlow viral propagation during initial phase of infection leads to viral persistence in miceHaifeng C. Xu0Ruifeng Wang1Prashant V. Shinde2Lara Walotka3Anfei Huang4Gereon Poschmann5Jun Huang6Wei Liu7Kai Stühler8Heiner Schaal9Andreas Bergthaler10Aleksandra A. Pandyra11Cornelia Hardt12Karl S. Lang13Philipp A. Lang14Department of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityInstitute of Virology, Medical Faculty, Heinrich Heine University DüsseldorfDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityInstitute of Molecular Medicine I, Proteome research, Medical Faculty, Heinrich-Heine University DüsseldorfDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityInstitute of Molecular Medicine I, Proteome research, Medical Faculty, Heinrich-Heine University DüsseldorfInstitute of Virology, Medical Faculty, Heinrich Heine University DüsseldorfCeMM Research Center for Molecular Medicine of the Austrian Academy of SciencesDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityInstitute of Immunology, Medical Faculty, University of Duisburg-EssenInstitute of Immunology, Medical Faculty, University of Duisburg-EssenDepartment of Molecular Medicine II, Medical Faculty, Heinrich Heine UniversityUsing different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as a mechanism for immune evasion and viral persistence.https://doi.org/10.1038/s42003-021-02028-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Haifeng C. Xu Ruifeng Wang Prashant V. Shinde Lara Walotka Anfei Huang Gereon Poschmann Jun Huang Wei Liu Kai Stühler Heiner Schaal Andreas Bergthaler Aleksandra A. Pandyra Cornelia Hardt Karl S. Lang Philipp A. Lang
spellingShingle	Haifeng C. Xu Ruifeng Wang Prashant V. Shinde Lara Walotka Anfei Huang Gereon Poschmann Jun Huang Wei Liu Kai Stühler Heiner Schaal Andreas Bergthaler Aleksandra A. Pandyra Cornelia Hardt Karl S. Lang Philipp A. Lang Slow viral propagation during initial phase of infection leads to viral persistence in mice Communications Biology
author_facet	Haifeng C. Xu Ruifeng Wang Prashant V. Shinde Lara Walotka Anfei Huang Gereon Poschmann Jun Huang Wei Liu Kai Stühler Heiner Schaal Andreas Bergthaler Aleksandra A. Pandyra Cornelia Hardt Karl S. Lang Philipp A. Lang
author_sort	Haifeng C. Xu
title	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_short	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_full	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_fullStr	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_full_unstemmed	Slow viral propagation during initial phase of infection leads to viral persistence in mice
title_sort	slow viral propagation during initial phase of infection leads to viral persistence in mice
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-04-01
description	Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as a mechanism for immune evasion and viral persistence.
url	https://doi.org/10.1038/s42003-021-02028-x
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Slow viral propagation during initial phase of infection leads to viral persistence in mice

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