Secretome of Mesenchymal Stromal Cells Prevents Myofibroblasts Differentiation by Transferring Fibrosis-Associated microRNAs within Extracellular Vesicles

Secretome of Mesenchymal Stromal Cells Prevents Myofibroblasts Differentiation by Transferring Fibrosis-Associated microRNAs within Extracellular Vesicles

Fibroblasts differentiation into myofibroblasts is a central event of tissue fibrosis. Multipotent mesenchymal stromal cells (MSCs) secretome can interfere with fibrosis development; despite precise underlying mechanisms remain unclear. In this study, we tested the hypothesis that MSC secretome can...

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Bibliographic Details
Main Authors: Nataliya Basalova, Georgy Sagaradze, Mikhail Arbatskiy, Evgeniy Evtushenko, Konstantin Kulebyakin, Olga Grigorieva, Zhanna Akopyan, Natalia Kalinina, Anastasia Efimenko
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
mesenchymal stem/stromal cells
fibrosis
myofibroblasts
secretome
extracellular vesicles
microRNA
Online Access:https://www.mdpi.com/2073-4409/9/5/1272

Internet

https://www.mdpi.com/2073-4409/9/5/1272

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