The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein

The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein

The aberrant accumulation of alpha-synuclein (α-syn) is believed to contribute to the onset and pathogenesis of Parkinson's disease (PD). The autophagy-lysosome pathway (ALP) is responsible for the high capacity clearance of α-syn. ALP dysfunction is documented in PD and pre-clinical evidence s...

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Bibliographic Details
Main Authors: Michael P. Nelson, Michel Boutin, Tonia E. Tse, Hailin Lu, Emily D. Haley, Xiaosen Ouyang, Jianhua Zhang, Christiane Auray-Blais, John J. Shacka
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Neurobiology of Disease
Subjects:
Alpha-Galactosidase A
Alpha-synuclein
Globotriaosylceramide
Glycosphingolipids
Parkinson's disease
Lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302723

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http://www.sciencedirect.com/science/article/pii/S0969996117302723

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