HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry

HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry

The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain and gain mechanistic insights into the process.

Bibliographic Details
Main Authors: Vincent V. Pham, Carolina Salguero, Shamsun Nahar Khan, Jennifer L. Meagher, W. Clay Brown, Nicolas Humbert, Hugues de Rocquigny, Janet L. Smith, Victoria M. D’Souza
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06591-6

Internet

https://doi.org/10.1038/s41467-018-06591-6

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