PD-L1+ Regulatory B Cells Are Significantly Decreased in Rheumatoid Arthritis Patients and Increase After Successful Treatment

PD-L1+ Regulatory B Cells Are Significantly Decreased in Rheumatoid Arthritis Patients and Increase After Successful Treatment

Background: B cells play an important role in the development and maintenance of rheumatoid arthritis (RA). Although IL-10–producing B cells represent a major subset of regulatory B cells (Bregs) able to suppress autoimmune and inflammatory responses, recent reports showed that B cell-mediated immun...

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Bibliographic Details
Main Authors: Estefanía R. Zacca, Luisina I. Onofrio, Cristina D. V. Acosta, Paola V. Ferrero, Sergio M. Alonso, María C. Ramello, Eduardo Mussano, Laura Onetti, Isaac I. Cadile, Maria I. Stancich, Maria C. Taboada Bonfanti, Carolina L. Montes, Eva V. Acosta Rodríguez, Adriana Gruppi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
bregs
PD-L1
rheumatic diseases
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02241/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02241/full

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