Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors

Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors

Abstract Background Mice lacking Kalirin-7 (Kal7KO), a Rho GDP/GTP exchange factor, self-administer cocaine at a higher rate than wildtype mice, and show an exaggerated locomotor response to experimenter-administered cocaine. Kal7, which localizes to post-synaptic densities at glutamatergic synapses...

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Bibliographic Details
Main Authors: Taylor P. LaRese, Yan Yan, Betty A. Eipper, Richard E. Mains
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Neuroscience
Subjects:
Cre recombinase
GDP/GTP exchange factor
GEF
Trio
Anxiety
Locomotor sensitization
Online Access:http://link.springer.com/article/10.1186/s12868-017-0363-2

Internet

http://link.springer.com/article/10.1186/s12868-017-0363-2

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