Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen.

Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen.

Neprilysin (NEP) is an endogenous protease that degrades a wide range of peptides including amyloid beta (Aβ), the main pathological component of Alzheimer's disease (AD). We have engineered NEP as a potential therapeutic for AD but found in pre-clinical safety testing that this variant increas...

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Bibliographic Details
Main Authors: Matthew Burrell, Simon J Henderson, Anna Ravnefjord, Fritz Schweikart, Susan B Fowler, Susanne Witt, Kenny M Hansson, Carl I Webster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4954676?pdf=render

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http://europepmc.org/articles/PMC4954676?pdf=render

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