Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy

Energy Metabolism and Redox State in Brains of Wistar Audiogenic Rats, a Genetic Model of Epilepsy

The Wistar Audiogenic Rat (WAR) strain is a genetic model of epilepsy, specifically brainstem-dependent tonic-clonic seizures, triggered by acute auditory stimulation. Chronic audiogenic seizures (audiogenic kindling) mimic temporal lobe epilepsy, with significant participation of the hippocampus, a...

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Bibliographic Details
Main Authors: Carlos Roberto Porto Dechandt, Gustavo Duarte Ferrari, Jonathas Rodrigo dos Santos, José Antonio Cortes de Oliveira, Rui Milton Patrício da Silva-Jr, Alexandra Olimpio Siqueira Cunha, Norberto Garcia-Cairasco, Luciane Carla Alberici
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neurology
Subjects:
mitochondria
wistar audiogenic rats (WAR)
reactive oxygen species
audiogenic kindling
2,4-dinitrophenol (DNP)
N-acetylcysteine (NAC)
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01007/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.01007/full

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