LT-K63 Enhances B Cell Activation and Survival Factors in Neonatal Mice That Translates Into Long-Lived Humoral Immunity

LT-K63 Enhances B Cell Activation and Survival Factors in Neonatal Mice That Translates Into Long-Lived Humoral Immunity

Adjuvants enhance magnitude and duration of immune responses induced by vaccines. In this study we assessed in neonatal mice if and how the adjuvant LT-K63 given with a pneumococcal conjugate vaccine, Pnc1-TT, could affect the expression of tumor necrosis factor receptor (TNF-R) superfamily members,...

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Bibliographic Details
Main Authors: Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Gudbjorg Julia Magnusdottir, Giuseppe Del Giudice, Ingileif Jonsdottir, Stefania P. Bjarnarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
neonatal vaccination
adjuvant
B cell subsets
BAFF-R
BCMA
plasma cell survival
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.527310/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.527310/full

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