Germline TP53 and MSH6 mutations implicated in sporadic triple-negative breast cancer (TNBC): a preliminary study

Germline TP53 and MSH6 mutations implicated in sporadic triple-negative breast cancer (TNBC): a preliminary study

Abstract Background Germline BRCA1/2 prevalence is relatively low in sporadic triple-negative breast cancer (TNBC). We hypothesized that non-BRCA genes may also have significant germline contribution to Chinese sporadic TNBC, and the somatic mutational landscape of TNBC may vary between ethnic group...

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Bibliographic Details
Main Authors: Dandan Yi, Lei Xu, Jiaqi Luo, Xiaobin You, Tao Huang, Yi Zi, Xiaoting Li, Ru Wang, Zaixuan Zhong, Xiaoqiao Tang, Ang Li, Yujian Shi, Jianmei Rao, Yifen Zhang, Jianfeng Sang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Human Genomics
Subjects:
TP53
MSH6
NF1
POLE
TNBC
Multi-gene testing
Online Access:http://link.springer.com/article/10.1186/s40246-018-0186-y

Internet

http://link.springer.com/article/10.1186/s40246-018-0186-y

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