Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor.

Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor.

Small differences in the chemical structures of ligands can be responsible for agonism, neutral antagonism or inverse agonism toward a G-protein-coupled receptor (GPCR). Although each ligand may stabilize the receptor conformation in a different way, little is known about the precise conformational...

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Bibliographic Details
Main Authors: Shin-ichiro Miura, Yoshihiro Kiya, Hiroyuki Hanzawa, Naoki Nakao, Masahiro Fujino, Satoshi Imaizumi, Yoshino Matsuo, Hiroaki Yanagisawa, Hiroyuki Koike, Issei Komuro, Sadashiva S Karnik, Keijiro Saku
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3375280?pdf=render

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http://europepmc.org/articles/PMC3375280?pdf=render

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