Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models

Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models

Oral squamous cell carcinoma (OSCC) develops through the multistep malignant progression of squamous epithelium. This process can be prevented by PD-1 blockade in a mouse model for oral carcinogenesis. OSCCs exhibit a high incidence of <i>p53</i> mutations that confer oncogenic gain-of-f...

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Bibliographic Details
Main Authors: Jin Wang, Yuan Hu, Vicente Escamilla-Rivera, Cassandra L. Gonzalez, Lin Tang, Bingbing Wang, Adel K. El-Naggar, Jeffrey N. Myers, Carlos Caulin
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
immunoprevention
oral cancer
mutant p53
PD-1
premalignancy
Online Access:https://www.mdpi.com/2072-6694/13/6/1471

Internet

https://www.mdpi.com/2072-6694/13/6/1471

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