New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions

New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions

A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions using microwave assisted synthesis methodology. This approach for the aminodehalogenation reaction was chosen due to higher yields and shorter...

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Bibliographic Details
Main Authors: Ondrej Jandourek, Martin Dolezal, Jiri Kunes, Vladimir Kubicek, Pavla Paterova, Matus Pesko, Vladimir Buchta, Katarina Kralova, Jan Zitko
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
aminodehalogenation reaction
antifungal activity
inhibition of photosynthetic electron transport
pyrazinamide
microwave-assisted synthesis
structure-activity relationships
Online Access:http://www.mdpi.com/1420-3049/19/7/9318

Internet

http://www.mdpi.com/1420-3049/19/7/9318

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