No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach

No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach

Objective: HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury. We investigated the impact of kick-and-kill on plasma neurofilament light (NfL), a marker of neuro-axonal injury, in...

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Bibliographic Details
Main Authors: Jasmini Alagaratnam, Wolfgang Stöhr, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Sarah Pett, Mark Nelson, Amanda Clarke, Nneka Nwokolo, Margaret A. Johnson, Maryam Khan, Tomas Hanke, Jakub Kopycinski, Lucy Dorrell, Julie Fox, Sabine Kinloch, Jonathan Underwood, Matthew Pace, John Frater, Alan Winston, Sarah Fidler
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Virus Eradication
Subjects:
Neurofilament light chain protein
Neuro-axonal injury
Vorinostat
HIV-1 therapeutic vaccination
HIV-1 remission approach
Kick and kill
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664021000297

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http://www.sciencedirect.com/science/article/pii/S2055664021000297

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