Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

Glial cell line-derived neurotrophic factor (GDNF) supports function and survival of dopamine neurons that degenerate in Parkinson’s disease (PD). Ectopic delivery of GDNF in clinical trials to treat PD is safe but lacks significant therapeutic effect. In pre-clinical models, ectopic GDNF is effecti...

Full description

Bibliographic Details
Main Authors: Giorgio Turconi, Jaakko Kopra, Vootele Võikar, Natalia Kulesskaya, Carolina Vilenius, T. Petteri Piepponen, Jaan-Olle Andressoo
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
GDNF
safety evaluation
motor function
dopamine system
long-term side effects
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300632

Internet

http://www.sciencedirect.com/science/article/pii/S2329050120300632

Similar Items