Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.

Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.

Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain...

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Main Authors: Iori Sakakibara, Marc Santolini, Arnaud Ferry, Vincent Hakim, Pascal Maire
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4031048?pdf=render
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spelling doaj-e680f3e7c5204f57b9c868d5691764852020-11-24T22:18:41ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042014-01-01105e100438610.1371/journal.pgen.1004386Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.Iori SakakibaraMarc SantoliniArnaud FerryVincent HakimPascal MaireThousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.http://europepmc.org/articles/PMC4031048?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Iori Sakakibara
Marc Santolini
Arnaud Ferry
Vincent Hakim
Pascal Maire
spellingShingle Iori Sakakibara
Marc Santolini
Arnaud Ferry
Vincent Hakim
Pascal Maire
Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.
PLoS Genetics
author_facet Iori Sakakibara
Marc Santolini
Arnaud Ferry
Vincent Hakim
Pascal Maire
author_sort Iori Sakakibara
title Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.
title_short Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.
title_full Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.
title_fullStr Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.
title_full_unstemmed Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.
title_sort six homeoproteins and a iinc-rna at the fast myh locus lock fast myofiber terminal phenotype.
publisher Public Library of Science (PLoS)
series PLoS Genetics
issn 1553-7390
1553-7404
publishDate 2014-01-01
description Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.
url http://europepmc.org/articles/PMC4031048?pdf=render
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AT marcsantolini sixhomeoproteinsandaiincrnaatthefastmyhlocuslockfastmyofiberterminalphenotype
AT arnaudferry sixhomeoproteinsandaiincrnaatthefastmyhlocuslockfastmyofiberterminalphenotype
AT vincenthakim sixhomeoproteinsandaiincrnaatthefastmyhlocuslockfastmyofiberterminalphenotype
AT pascalmaire sixhomeoproteinsandaiincrnaatthefastmyhlocuslockfastmyofiberterminalphenotype
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