Efficient Synthesis of UDP-Furanoses via 4,5-Dicyanoimidazole(DCI)-Promoted Coupling of Furanosyl-1-Phosphates with Uridine Phosphoropiperidate

Efficient Synthesis of UDP-Furanoses via 4,5-Dicyanoimidazole(DCI)-Promoted Coupling of Furanosyl-1-Phosphates with Uridine Phosphoropiperidate

A P(V)-N activation method based on nucleoside phosphoropiperidate/DCI system has been developed for improved synthesis of diverse UDP-furanoses. The reaction conditions including temperature, amount of activator, and reaction time were optimized to alleviate the degradation of UDP-furanoses to cycl...

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Bibliographic Details
Main Authors: Wei-Jie Chen, Shuai-Bo Han, Zhen-Biao Xie, Hua-Shan Huang, Duo-Hua Jiang, Shan-Shan Gong, Qi Sun
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
NDP-sugar
P(V)-N activation
furanosyl-1-phosphate
nucleoside phosphoropiperidate
4,5-dicyanoimidazole
Online Access:https://www.mdpi.com/1420-3049/24/4/655

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https://www.mdpi.com/1420-3049/24/4/655

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