Alleviation of cognitive deficits and high copper levels by an NMDA receptor antagonist in a rat depression model

Alleviation of cognitive deficits and high copper levels by an NMDA receptor antagonist in a rat depression model

Background: Major depressive disorder (MDD) is frequently associated with cognitive deficits and high copper levels. Dysfunction of N-methyl-d-aspartate (NMDA) receptors has been postulated to underlie MDD pathogenesis. This study sought to investigate the curative effect of the NMDA receptor antago...

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Bibliographic Details
Main Authors: Zhinan Li, Guodong Wang, Shuming Zhong, Xiaoxiao Liao, Shunkai Lai, Yanyan Shan, Junhao Chen, Lu Zhang, Qianyi Lu, Shiyi Shen, Hui Huang, Yiliang Zhang, Li Zhang, Yanbin Jia
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Comprehensive Psychiatry
Subjects:
Depression
NMDA receptor
Copper ions
Memantine
Cognitive function
Online Access:http://www.sciencedirect.com/science/article/pii/S0010440X20300420

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http://www.sciencedirect.com/science/article/pii/S0010440X20300420

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