Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity

Abstract In vitro induced human regulatory T cells (iTregs) have demonstrated in vivo therapeutic utility, but pathways regulating their function have not been elucidated. Here, we report that human iTregs generated in vitro from naïve cord blood cells preferentially recruit Disc large homolog 1 (Dl...

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Bibliographic Details
Main Authors: Alexandra Zanin-Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan, Bruce R. Blazar, Michael L. Dustin
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04053-5

Internet

https://doi.org/10.1038/s41598-017-04053-5

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