Angiotensin II Type I Receptor Antagonism Attenuates Nicotine-Induced Cardiac Remodeling, Dysfunction, and Aggravation of Myocardial Ischemia-Reperfusion Injury in Rats

Angiotensin II Type I Receptor Antagonism Attenuates Nicotine-Induced Cardiac Remodeling, Dysfunction, and Aggravation of Myocardial Ischemia-Reperfusion Injury in Rats

Increased exposure to nicotine contributes to the development of cardiac dysfunction by promoting oxidative stress, fibrosis, and inflammation. These deleterious events altogether render cardiac myocytes more susceptible to acute cardiac insults such as ischemia-reperfusion (I/R) injury. This study...

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Bibliographic Details
Main Authors: Anand Ramalingam, Siti Balkis Budin, Norsyahida Mohd. Fauzi, Rebecca H. Ritchie, Satirah Zainalabidin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
cardiac fibrosis
hypertension
inflammation
irbesartan
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01493/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01493/full

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