Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung

Toxic Acetaminophen Exposure Induces Distal Lung ER Stress, Proinflammatory Signaling, and Emphysematous Changes in the Adult Murine Lung

Clinical studies have demonstrated a strong association between both acute toxic exposure and the repetitive, chronic exposure to acetaminophen (APAP) with pulmonary dysfunction. However, the mechanisms underlying this association are unknown. Preclinical reports have demonstrated that significant b...

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Bibliographic Details
Main Authors: Jeryl Sandoval, David J. Orlicky, Ayed Allawzi, Brittany Butler, Cynthia Ju, Caroline T. Phan, Roy Toston, Robyn De Dios, Leanna Nguyen, Sarah McKenna, Eva Nozik-Grayck, Clyde J. Wright
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/7595126

Internet

http://dx.doi.org/10.1155/2019/7595126

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