Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.

Amino acid signaling mediated by the activation of mechanistic target of rapamycin complex 1 (mTORC1) is fundamental to cell growth and metabolism. However, how cells negatively regulate amino acid signaling remains largely unknown. Here, we show that interaction between 4F2 heavy chain (4F2hc), a s...

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Bibliographic Details
Main Authors: Liang Weng, Yi-Peng Han, Atsushi Enomoto, Yasuyuki Kitaura, Shushi Nagamori, Yoshikatsu Kanai, Naoya Asai, Jian An, Maki Takagishi, Masato Asai, Shinji Mii, Takashi Masuko, Yoshiharu Shimomura, Masahide Takahashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2005090

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https://doi.org/10.1371/journal.pbio.2005090

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