Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male Rats

Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male Rats

Antidepressant-related sexual dysfunction is a frequent adverse event caused by serotonergic activation that intensely affects quality of life and adherence in depressed patients. The dopamine system has multiple effects promoting sexual behavior, but no studies have been carried out to confirm dopa...

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Bibliographic Details
Main Authors: Yanira Santana, Angel L. Montejo, Javier Martín, Ginés LLorca, Gloria Bueno, Juan Luis Blázquez
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Journal of Clinical Medicine
Subjects:
dopaminergic system
paroxetine
agomelatine
immunohistochemical study
sexual dysfunction
male rats
Online Access:https://www.mdpi.com/2077-0383/8/2/133

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https://www.mdpi.com/2077-0383/8/2/133

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