TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis

TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis

Cytomegaloviruses all encode the viral inhibitor of caspase-8-induced apoptosis (vICA). After binding to this initiator caspase, vICA blocks caspase-8 proteolytic activity and ability to activate caspase-3 and/or caspase-7. In this manner, vICA has long been known to prevent apoptosis triggered via...

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Bibliographic Details
Main Authors: Pratyusha Mandal, A. Louise McCormick, Edward S. Mocarski
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Viruses
Subjects:
apoptosis
extrinsic apoptosis
intrinsic apoptosis
pyroptosis
necroptosis
inflammation
Online Access:https://www.mdpi.com/1999-4915/12/11/1221

Internet

https://www.mdpi.com/1999-4915/12/11/1221

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