Methylselenol Produced In Vivo from Methylseleninic Acid or Dimethyl Diselenide Induces Toxic Protein Aggregation in <i>Saccharomyces cerevisiae</i>

Methylselenol Produced In Vivo from Methylseleninic Acid or Dimethyl Diselenide Induces Toxic Protein Aggregation in <i>Saccharomyces cerevisiae</i>

Methylselenol (MeSeH) has been suggested to be a critical metabolite for anticancer activity of selenium, although the mechanisms underlying its activity remain to be fully established. The aim of this study was to identify metabolic pathways of MeSeH in <em>Saccharomyces cerevisiae</em>...

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Bibliographic Details
Main Authors: Marc Dauplais, Katarzyna Bierla, Coralie Maizeray, Roxane Lestini, Ryszard Lobinski, Pierre Plateau, Joanna Szpunar, Myriam Lazard
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
methylselenol
diselenide
methylseleninic acid
thiol/disulfide exchange
redox equilibrium
<i>Saccharomyces cerevisiae</i> metabolism
Online Access:https://www.mdpi.com/1422-0067/22/5/2241

Internet

https://www.mdpi.com/1422-0067/22/5/2241

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