Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis.

Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis.

Hyperplasia of synovial fibroblasts, infiltration with inflammatory cytokines, and tissue hypoxia are the major characteristics of rheumatoid arthritis (RA). Interleukin 33 (IL-33) is a newly identified inflammatory cytokine exacerbating the disease severity of RA. Hypoxia-inducible factor-1α (HIF-1...

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Bibliographic Details
Main Authors: Fanlei Hu, Lianjie Shi, Rong Mu, Jiaxin Zhu, Yingni Li, Xiaoxu Ma, Chun Li, Rulin Jia, Dongyue Yang, Yun Li, Zhanguo Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3744448?pdf=render

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http://europepmc.org/articles/PMC3744448?pdf=render

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