Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information.

Thermodynamic additivity of sequence variations: an algorithm for creating high affinity peptides without large libraries or structural information.

BACKGROUND: There is a significant need for affinity reagents with high target affinity/specificity that can be developed rapidly and inexpensively. Existing affinity reagent development approaches, including protein mutagenesis, directed evolution, and fragment-based design utilize large libraries...

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Bibliographic Details
Main Authors: Matthew P Greving, Paul E Belcher, Chris W Diehnelt, Maria J Gonzalez-Moa, Jack Emery, Jinglin Fu, Stephen Albert Johnston, Neal W Woodbury
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2978705?pdf=render

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http://europepmc.org/articles/PMC2978705?pdf=render

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