Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.

Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure.

Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought t...

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Bibliographic Details
Main Authors: Ting-Ting Tang, Zheng-Feng Zhu, Jun Wang, Wen-Cai Zhang, Xin Tu, Hong Xiao, Xin-Ling Du, Jia-Hong Xia, Nian-Guo Dong, Wei Su, Ni Xia, Xin-Xin Yan, Shao-Fang Nie, Juan Liu, Su-Feng Zhou, Rui Yao, Jiang-Jiao Xie, Harish Jevallee, Xiang Wang, Meng-Yang Liao, Guo-Ping Shi, Michael Fu, Yu-Hua Liao, Xiang Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174174?pdf=render

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http://europepmc.org/articles/PMC3174174?pdf=render

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