TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System

Ten-eleven translocation-2 (TET2) protein is a DNA demethylase that regulates gene expression through DNA demethylation and also plays important roles in various diseases including atherosclerosis. Endothelial dysfunction represents an early key event in atherosclerotic disease. The cystathionine-γ-...

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Bibliographic Details
Main Authors: Juan Peng, Zhi-Han Tang, Zhong Ren, Bei He, Yun Zeng, Lu-Shan Liu, Zuo Wang, Dang-Heng Wei, Xi-Long Zheng, Zhi-Sheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Pharmacology
Subjects:
ten-eleven translocation-2
cystathionine-γ-lyase/hydrogen sulfide
endothelial dysfunction
DNA demethylation
oxidized low-density lipoprotein
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00486/full

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00486/full

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