Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis

Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis

Abstract Background Consistently with their diagnostic and prognostic value, autoantibodies specific for systemic sclerosis (SSc) embedded in immune complexes (ICs) elicited a pro-inflammatory and pro-fibrotic cascade in healthy skin fibroblasts, engaging Toll-like receptors (TLRs) via their nucleic...

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Bibliographic Details
Main Authors: Elena Raschi, Daniela Privitera, Caterina Bodio, Paola Adele Lonati, Maria Orietta Borghi, Francesca Ingegnoli, Pier Luigi Meroni, Cecilia Beatrice Chighizola
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Autoantibodies
Immune complexes
Toll-like receptors
Endothelial cells
Fibrosis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02360-3

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http://link.springer.com/article/10.1186/s13075-020-02360-3

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