Breast cancer pathogenesis is linked to the intra-tumoral estrogen sulfotransferase (hSULT1E1) expressions regulated by cellular redox dependent Nrf-2/NFκβ interplay

Breast cancer pathogenesis is linked to the intra-tumoral estrogen sulfotransferase (hSULT1E1) expressions regulated by cellular redox dependent Nrf-2/NFκβ interplay

Abstract Background Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinoge...

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Bibliographic Details
Main Authors: Aarifa Nazmeen, Guangping Chen, Tamal Kanti Ghosh, Smarajit Maiti
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cancer Cell International
Subjects:
Breast cancer
SULT1E1 redox regulation
Estrogen
Nrf2 and NFκβ
Xenograft
Online Access:http://link.springer.com/article/10.1186/s12935-020-1153-y

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http://link.springer.com/article/10.1186/s12935-020-1153-y

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