Development of Sensitive Droplet Digital PCR Assays for Detecting Urinary <i>TERT</i> Promoter Mutations as Non-Invasive Biomarkers for Detection of Urothelial Cancer

Development of Sensitive Droplet Digital PCR Assays for Detecting Urinary <i>TERT</i> Promoter Mutations as Non-Invasive Biomarkers for Detection of Urothelial Cancer

Somatic mutations in the <i>telomerase reverse transcriptase</i> (<i>TERT</i>) promoter regions are frequent events in urothelial cancer (UC) and their detection in urine (supernatant cell-free DNA or DNA from exfoliated cells) could serve as putative non-invasive biomarkers...

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Bibliographic Details
Main Authors: Md Ismail Hosen, Nathalie Forey, Geoffroy Durand, Catherine Voegele, Selin Bilici, Patrice Hodonou Avogbe, Tiffany Myriam Delhomme, Matthieu Foll, Arnaud Manel, Emmanuel Vian, Sonia Meziani, Berengere De Tilly, Gilles Polo, Olesia Lole, Pauline Francois, Antoine Boureille, Eduard Pisarev, Andrei R. O. S. E. Salas, Sara Monteiro-Reis, Rui Henrique, Graham Byrnes, Carmen Jeronimo, Ghislaine Scelo, James D. McKay, Florence Le Calvez-Kelm, Maria Zvereva
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
droplet digital PCR
liquid biopsy
bladder cancer
<i>TERT</i> promoter mutations
urinary biomarkers
Online Access:https://www.mdpi.com/2072-6694/12/12/3541

Internet

https://www.mdpi.com/2072-6694/12/12/3541

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