Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.

Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.

Global DNA hypomethylation is a hallmark of cancer cells, but its molecular mechanisms have not been elucidated. Here, we show that the disruption of Dnmt1/PCNA/UHRF1 interactions promotes a global DNA hypomethylation in human gliomas. We then demonstrate that the Dnmt1 phosphorylations by Akt and/o...

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Bibliographic Details
Main Authors: Eric Hervouet, Lisenn Lalier, Emilie Debien, Mathilde Cheray, Audrey Geairon, Hélène Rogniaux, Delphine Loussouarn, Stéphane A Martin, François M Vallette, Pierre-François Cartron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2894052?pdf=render

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http://europepmc.org/articles/PMC2894052?pdf=render

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