Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines

Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines

The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moie...

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Bibliographic Details
Main Authors: Martins Rucins, Pavels Dimitrijevs, Klavs Pajuste, Oksana Petrichenko, Ludmila Jackevica, Anita Gulbe, Signe Kibilda, Krisjanis Smits, Mara Plotniece, Dace Tirzite, Karlis Pajuste, Arkadij Sobolev, Janis Liepins, Ilona Domracheva, Aiva Plotniece
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceutics
Subjects:
synthetic lipids
pyridinium and propargyl moieties
nanoparticles
self-assembling properties
DLS
TEM
cytotoxicity
toxicity on microorganisms
phospholipid binding
Online Access:http://www.mdpi.com/1999-4923/11/3/115

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http://www.mdpi.com/1999-4923/11/3/115

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