Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study

Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study

Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast cancers included. CSCs selectively overexpress key mitochondrial-related proteins and inhibition of mitochondrial function may...

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Bibliographic Details
Main Authors: Cristian Scatena, Manuela Roncella, Antonello Di Paolo, Paolo Aretini, Michele Menicagli, Giovanni Fanelli, Carolina Marini, Chiara Maria Mazzanti, Matteo Ghilli, Federica Sotgia, Michael P. Lisanti, Antonio Giuseppe Naccarato
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
doxycycline
mitochondria
cancer stem cells
translational study
mitochondrial biogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00452/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00452/full

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