Human ALKBH6 Is Required for Maintenance of Genomic Stability and Promoting Cell Survival During Exposure of Alkylating Agents in Pancreatic Cancer

Human ALKBH6 Is Required for Maintenance of Genomic Stability and Promoting Cell Survival During Exposure of Alkylating Agents in Pancreatic Cancer

Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. There are nine types of ALKBH (ALKBH1-8 and FTO) identified in humans. In particular, certain types of ALKBH enzymes are dioxygenases that directly reverse DNA methylation damage v...

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Bibliographic Details
Main Authors: Shengyuan Zhao, Rodan Devega, Aaliyah Francois, Dawit Kidane
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Genetics
Subjects:
alkbh6
alkylating DNA damage
pancreatic cancer
DNA repair
Alkb E. coli
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.635808/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.635808/full

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