Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages

Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages

The apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) is an adaptor molecule that mediates inflammatory and apoptotic signals. Legionella pneumophila (L. pneumophila) is an intracellular bacterium and the causative agent of Legionnaire’s pneumonia. L. pneumophila...

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Bibliographic Details
Main Authors: Amal O Amer, Dalia H.A. Abdelaziz, Mikhail A Gavrilin, Anwari eAkhter, Kyle eCaution, Sheetal eKotrange, Arwa eAbu Khweek, Basant A. Abdulrahman, Zeinab A. Hassan, Fathia Z. El-Sharkawi, Simranjit S. Bedi, Katherine eLadner, Mahmoud eMostafa, Andrea eDoseff, Elba M Gonzalez-Mejia, Dennis eGuttridge, Thirumala-Devi eKanneganti, Clay B. Marsh, Mark D. Wewers
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Legionella pneumophila
Inflammasome
caspase-1
ASC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00018/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00018/full

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