Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells

Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells

Abstract Background Angiogenesis, as an endogenous repair mechanism, plays crucial roles in wound healing and tissue regeneration. However, this process is impaired in the elderly due to aging-related vascular endothelial dysfunction. This study was aimed to explore the pro-angiogenic effects of exo...

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Bibliographic Details
Main Authors: Bi Chen, Yongjin Sun, Juntao Zhang, Qingwei Zhu, Yunlong Yang, Xin Niu, Zhifeng Deng, Qing Li, Yang Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Stem Cell Research & Therapy
Subjects:
Senescence
Angiogenesis
Exosomes
Embryonic stem cells
Nrf2
Online Access:http://link.springer.com/article/10.1186/s13287-019-1253-6

Internet

http://link.springer.com/article/10.1186/s13287-019-1253-6

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