Conformation of the nuclear pore in living cells is modulated by transport state

Conformation of the nuclear pore in living cells is modulated by transport state

While the static structure of the nuclear pore complex (NPC) continues to be refined with cryo-EM and x-ray crystallography, in vivo conformational changes of the NPC remain under-explored. We developed sensors that report on the orientation of NPC components by rigidly conjugating mEGFP to differen...

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Bibliographic Details
Main Authors: Joan Pulupa, Harriet Prior, Daniel S Johnson, Sanford M Simon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
total internal reflection
polarization microscopy
conformational dynamics
protein dynamics
nuclear cytoplasmic trafficking
fluorescence microscopy
Online Access:https://elifesciences.org/articles/60654

Internet

https://elifesciences.org/articles/60654

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