Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression

Abstract Background Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androgen-dependent mechanisms of repression in PCa and m...

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Bibliographic Details
Main Authors: Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner, Bharati Bapat
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Clinical Epigenetics
Subjects:
Prostate cancer
TET2 knockout
Differential methylation profiling
Integrative analysis
Tumor progression
Online Access:http://link.springer.com/article/10.1186/s13148-019-0651-z

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http://link.springer.com/article/10.1186/s13148-019-0651-z

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