Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification

Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification

Common variable immune deficiency disorder (CVID) is the most clinically relevant cause of antibody failure. It is a highly heterogeneous disease with different underlying etiologies. CVID has been associated with a quantitative B cell defect, however, little is known about the quality of B cells pr...

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Bibliographic Details
Main Authors: Pauline A. van Schouwenburg, Hanna IJspeert, Ingrid Pico-Knijnenburg, Virgil A. S. H. Dalm, P. Martin van Hagen, David van Zessen, Andrew P. Stubbs, Smita Y. Patel, Mirjam van der Burg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
common variable immune deficiency disorder
B-cell receptor repertoire
repertoire formation
repertoire specification
germinal center
somatic hypermutation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02545/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02545/full

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