Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model.

Fatal neurodegenerative prion diseases are caused by the transmissible PrP(Sc) prion agent whose initial replication after peripheral inoculation takes place in follicular dendritic cells present in germinal centers of lymphoid organs. However, prion replication also occurs in lymphoid cells. To ass...

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Bibliographic Details
Main Authors: Corinne Loeuillet, Catherine Lemaire-Vieille, Philippe Naquet, Marie-France Cesbron-Delauw, Jean Gagnon, Jean-Yves Cesbron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2950141?pdf=render