Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Abstract Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4% of total α-synuclein is phospho...

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Bibliographic Details
Main Authors: Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Shingo Koyama, Takeo Kato
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Acta Neuropathologica Communications
Subjects:
Parkinson’s disease
α–Synuclein
Phosphorylation
Aggregation
Mitochondrial impairment
Proteasome pathway
Online Access:http://link.springer.com/article/10.1186/s40478-017-0452-6

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http://link.springer.com/article/10.1186/s40478-017-0452-6

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