Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls

Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls

Polychlorinated dibenzo-p-dioxins (PCDDs) and coplanar polychlorinated biphenyls (PCBs) contribute to dioxin toxicity in humans and wildlife after bioaccumulation through the food chain from the environment. The authors examined human and rat cytochrome P450 (CYP)-dependent metabolism of PCDDs and P...

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Bibliographic Details
Main Authors: Hideyuki Inui, Toshimasa Itoh, Keiko Yamamoto, Shin-Ichi Ikushiro, Toshiyuki Sakaki
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
CYP1A1
cytochrome P450 monooxygenase
hydroxylation
polychlorinated biphenyl
polychlorinated dibenzo-p-dioxin
sulfotransferase
UDP-glucuronosyltransferase
Online Access:http://www.mdpi.com/1422-0067/15/8/14044

Internet

http://www.mdpi.com/1422-0067/15/8/14044

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